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Reliability guarantee framework for the Sichuan–Tibet Railway

Frontiers of Engineering Management 2021, Volume 8, Issue 4, Pages 480-491 doi: 10.1007/s42524-021-0170-4

Abstract: This study proposes a novel reliability framework to guarantee the ideal operation state of the Sichuan–Tibet

Keywords： Sichuan–Tibet Railway operational efficiency reliability guarantee Nine-Connotation implementation

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration (FDA) approvals for various indications. To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic malignancies. However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or they reported life-threatening treatment-related damages to healthy tissues. The simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such toxicities. Alongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T therapies. Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis, and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone, Cosmc. Moreover, these glycoforms have been associated with various types of cancers, including prostate, breast, colon, gastric, and lung cancers. Here, we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

Keywords： cancer immunotherapy chimeric antigen receptor solid tumors tumor-associated antigen glycosylation O-glycans adoptive cell therapy

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Service Security of Underwater Tunnel Lining Structures and Corresponding Guarantee Countermeasures

He Chuan,Liu Sijin,Zhang Yuchun and Feng Kun

Strategic Study of CAE 2017, Volume 19, Issue 6, Pages 44-51 doi: 10.15302/J-SSCAE-2017.06.007

Abstract:

This paper analyzes four aspects of the safety problems in tunnel lining structures: design and construction, environmental erosion, sudden natural disasters, and sudden accidents. A survey of underwater tunneling such as the Huangpu River’s cross-river tunnel and the underground traffic tunnel in Shanghai was carried out, and the status quo of China’s underwater tunnel lining structure was analyzed. Based on these analyses, countermeasures guaranteeing the long-life security of underwater tunnel structures are being sought regarding tunnel construction, structural performance degradation, sudden natural disasters, and sudden accidents. These countermeasures are being sought to effectively protect and ensure the service performance of the tunnel structures during their entire life cycle. These security measures can ensure the safe performance of the structure during its entire life cycle, even under long service times. This research can serve as a reference for enhancing the structural security of underwater tunnels and other major tunnel structures.

Keywords： underwater tunnels service security security guarantee countermeasures long life structural defects

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Safety Guarantee Measures for Subsea Shield Tunnel Segments Based on Life Cycle Deterioration Analysis

Liu Sijin,He Chuan,Sun Qi and Feng Kun

Strategic Study of CAE 2017, Volume 19, Issue 6, Pages 52-60 doi: 10.15302/J-SSCAE-2017.06.008

Abstract:

The segment joint is the weak link in the lining structure of subsea tunnels, as it is under the continuous coupled effect of high water pressure and the corrosive seawater environment. If its performance deteriorates, it will seriously affect the safety of the lining structure of entire subsea shield tunnels. Based on an analysis of existing research into segment joint erosion and deterioration, a tunnel service time factor is introduced. Considering the influence of seawater pressure infiltration and chloride ion erosion and migration, a model analyzing the erosion and deterioration of the segment joint over its whole life cycle was subsequently established. The law governing the progressive erosion and deterioration of the segment joints of subsea tunnels over the entire life cycle was analyzed. The effects of seawater pressure and ion concentration on the erosion, deterioration, and steel corrosion of segment joints were studied. Based on the analysis of erosion and deterioration over the entire life cycle, economic and rational measures to ensure the long-term safety of the segment lining structure of subsea shield tunnels were proposed.

Keywords： shield tunnel safety guarantee deterioration analysis ion erosion segment joint

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Genetic Crop Improvement: A Guarantee for Sustainable Agricultural Production

Jianmin Wan

Engineering 2018, Volume 4, Issue 4, Pages 431-432 doi: 10.1016/j.eng.2018.07.019

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“Heavenly Road”: The Qinghai–Tibet Railway

Yongfu SUN

Frontiers of Engineering Management 2020, Volume 7, Issue 2, Pages 304-307 doi: 10.1007/s42524-019-0079-3

Abstract: Xiaobo WANG. [J]. Front. Eng, 2019, 6(1): 131-137.Peter REDFERN, Hua ZHONG. [J]. Front. Eng, 2017, 4(2): 193-200.Qixiang FAN. [J]. Front. Eng, 2017, 4(2): 231-237.Ming-zhou Liu,Cong-hu Liu,Mao-gen Ge,Yuan Zhang,Qing-hua Zhu. [J]. Front. Eng, 2016, 3(2): 144-146.Yu Zhao,Sheng-quan Wang,Ke-chao Zhu. [J]. Front. Eng, 2015, 2(1): 35-38.Ru-gui Chen,Jia-meng Chen. [J]. Front. Eng, 2014, 1(1): 52-61.An Wang. [J]. Front. Eng, 2014, 1(1): 13-17.

Keywords： permafrost protection sustainable development health guarantee system

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Toward Trustworthy Decision-Making for Autonomous Vehicles: A Robust Reinforcement Learning Approach with Safety Guarantees

Xiangkun He,Wenhui Huang,Chen Lv,

Engineering doi: 10.1016/j.eng.2023.10.005

Abstract: Moreover, we devise a safety mask to guarantee the collision safety of the autonomous driving agent during

Keywords： Autonomous vehicle Decision-making Reinforcement learning Adversarial attack Safety guarantee

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Evaluation of the contract reliability for alternative infrastructure project delivery: a contract engineering method

Bing WANG, Qingbin CUI, Shuibo ZHANG

Frontiers of Engineering Management 2019, Volume 6, Issue 2, Pages 239-248 doi: 10.1007/s42524-019-0018-3

Abstract: When designing contracts, governments usually offer incentives while requiring cost or time guaranteeThis study fills this gap by developing a methodology that analyzes the appropriateness of guarantee

Keywords： infrastructure development contract design contract reliability guarantee provision contract engineering

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Safety of Highway Bridges in China

Zhou Jianting and Zheng Dan

Strategic Study of CAE 2017, Volume 19, Issue 6, Pages 27-37 doi: 10.15302/J-SSCAE-2017.06.005

Abstract: Safety guarantee issues will become increasingly prominent.

Keywords： highway bridge safety guarantee technology

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Discussion on Long-Life Security Strategies for Railway Track Engineering

Wang Ping,Chen Rong and An Boyang

Strategic Study of CAE 2017, Volume 19, Issue 6, Pages 66-71 doi: 10.15302/J-SSCAE-2017.06.010

Abstract:

Although significant progress in the development of rail transportation infrastructure has been achieved in China, operational safety management and efficient maintenance still has numerous complicated problems to be solved, especially relating to insufficient service life. Therefore, it is particularly urgent to organize and implement a long-life security plan for railway track engineering. This paper first reviews recent achievements in the field of railway track engineering in China, and then introduces advancements in this field in developed countries. Compared to developed countries, current research into long-life safety in the field of railway track engineering in China has much room for improvement; there is the absence of a top-level design, a lack of systematic research work, and insufficient depth and breadth of research. This paper concludes by providing suggestions in terms of theoretical research, talent cultivation, intelligent information management, and performance improvement and recovery.

Keywords： railway track engineering long life safety guarantee Shift2Rail

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Wind Resistance Safety of Marine Bridge Engineering and Corresponding Guarantee Countermeasures

Liao Haili , Li Mingshui , Zhou Qian

Strategic Study of CAE 2019, Volume 21, Issue 3, Pages 12-17 doi: 10.15302/J-SSCAE-2019.03.012

Abstract:

Compared with that of the offshore and inland long-span bridges, the wind field of marine bridges will be more complicated, and their wind resistance safety will inevitably become tougher. This paper first analyzes the status quo of wind-resistance research of long-span bridges, and then focuses on the difficulties and technical problems regarding four aspects: wind field characteristics, wind-resistant design theories, countermeasures for wind-induced vibration, and windbreak technologies for driving safety. Based on these analyses, countermeasures for guaranteeing wind resistance safety of marine bridges are proposed.

Keywords： marine bridge engineering wind resistance safety typhoon aerodynamic countermeasures

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Research on China’s Development Strategy for Marine Transportation Engineering

Task Force for the Study on Development Strategy of China’s Marine Engineering and Technology Marine Transportation Research Group

Strategic Study of CAE 2016, Volume 18, Issue 2, Pages 10-18 doi: 10.15302/J-SSCAE-2016.02.002

Abstract:

Marine transportation technology is the indispensable element requried for the marine exploration, ocean development, ocean resources management and maintaining China's maritime rights and interests. This paper identifies China's strategic needs for the the development of the marine transportation engineering capabilities and technology. At the same time, it also provides a in-depth analysis of the domestic and international development situation to map out the developmental direction and trends of future marine transportation engineering and technology in terms of the strategic positions, goals, strategic tasks and key areas of development for marine transportation equipment in China. Finally, this paper puts forward some policy measures and advice for the relevant departments of the industry to consider.

Keywords： marine transportation equipment important guarantee engineering and technology development strategy

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Oil alternative strategies and mid-long term development goals of bio-energy

Li Shizhong

Strategic Study of CAE 2011, Volume 13, Issue 6, Pages 101-107

Abstract:

The guarantee feedstock resources for developing bio-energy in China

Keywords： bio-energy feedstock guarantee bio-energy product developing goal

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Research on the Issue of a Cyber Sovereignty Guarantee

Zou Peng,He Jun,Zou Hongxia,Liu Yunjie

Strategic Study of CAE 2016, Volume 18, Issue 6, Pages 8-12 doi: 10.15302/J-SSCAE-2016.06.002

Abstract: cyberspace carries more and more national, public, and private interests, the issue of a cyber sovereignty guaranteesovereignty situation, this paper analyzes the main problems related to China's cyber sovereignty guarantee

Keywords： cyber sovereignty cyber right of independence cyber right of equality cyber right of self-defense cyber right of jurisdiction cyber border defense

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Energy Revolution and Security Guarantee of China’s Energy Economy

Huang Weihe, Mei Yingdan, Wu Lili, Liang Yunling, Zhao Xiaoli

Strategic Study of CAE 2021, Volume 23, Issue 1, Pages 124-132 doi: 10.15302/J-SSCAE-2021.01.018

Abstract:

Energy is the blood for economic operation. Energy structure adjustment may significantly impact the macroeconomic operation of a country. This study quantitatively estimates the effect of energy structure adjustment on energy prices and further evaluates the impact of the resulted price changes on macroeconomic operations using an econometric model and statistical methods. The results indicate that 1% increase of the proportion of natural gas consumption in the total energy consumption raises energy prices by 0.8% while 1% increase of the coal consumption ratio lowers energy prices by 0.2%. Moreover, technological progress, energy investment growth, increased marketization, and energy efficiency improvement are conducive to reducing energy prices. We conclude that China’s energy revolution is less likely to affect the security of the energy economy and the energy price rise remains within the acceptable range of national economy and energy consumption. To better ensure the security of energy economy in the process of China’s energy revolution, we propose that China should focus on technology innovation and deepen the reforms in the energy market to improve the competitiveness of the energy market. These measures are beneficial for mitigating the energy price increase pressure from energy revolution.

Keywords： energy revolution security of energy economy energy structure energy price national economy